Induction of anaesthesia with propofol using a target-controlled infusion system

Target-controlled infusion of propofol in dogs--evaluation of four targets for induction of anaesthesia.

Four groups of 20 dogs were anaesthetised by means of target-controlled infusions of propofol designed to achieve 2.5 microg/ml, 3.0 microg/ml, 3.5 microg/ml or 4.0 microg/ml of propofol in blood. The dogs' pulse rate and respiratory rate were recorded before premedication and induction, immediately after endotracheal intubation and three and five minutes later (times 0, 3 and 5, respectively),...

Comparison of target controlled infusion and total intravenous anaesthesia with propofol and remifentanil for lumbar microdiscectomy.

BACKGROUND Propofol is often combined with remifentanil for induction and maintenance of total intravenous anaesthesia. Target-controlled infusion (TCI) permits adapting infusion to pharmacokinetic models. In this study we compared depth of anaesthesia, haemodynamic variables and times to recovery in patients scheduled for lumbar microdiscectomy and receiving either manually controlled (group I...

Factors affecting recovery from anaesthesia with propofol–remifentanil target-controlled infusion in laparoscopic surgery

Objective This study was performed to analyse factors influencing the effect-site concentration (Ce) of propofol at return of consciousness (ROC) with target-controlled infusion of propofol-remifentanil after laparoscopic surgery. Methods In total, 112 patients who underwent laparoscopic surgery under general anaesthesia were given propofol at the target concentration of 3.5 µg/ml. Remifentanil...

Total Intravenous Anaesthesia in dogs: Development of a Target Controlled Infusion (TCI) scheme for propofol

Infusion rates for anaesthesia with propofol.

The infusion rate of propofol which would produce anaesthesia, when combined with nitrous oxide in oxygen, was studied in 75 fit unpremedicated patients undergoing body surface operations. The infusion rates were based on multiples of the median dose required to produce anaesthesia by intermittent injection in an additional 20 patients. The scatter of doses showed a right skew, for both intermi...